Table 5.

Characteristics of genes, mutations, and their effect on treatment present in patients with a TCF3::HLF translocation.

Gene and Locus	Gene Mutation	Effects on Pathology	Effects on Treatment
TCF3 (locus 17q22)	Fusion with HLF	Drives lineage identity and self-renewal by recruiting HLF binding sites to hematopoietic stem cell/myeloid lineage-associated enhancers	Resistance to cell apoptosis and venetoclax
BCL2 (locus 18q21.33)	High expression	Prolongs cell life by preventing the cell’s scheduled demise	Resistance to cell apoptosis and venetoclax
MYC (locus 8q24.21)	Deregulation of MYC expression	Has constitutive MYC activity and promotes oncogenesis	Resistance to treatment