Table 8.

Summary of genes responsible for activating metabolic pathways in ALL Ph-like; their mutations and treatment effects.

Gene and Locus	Gene Mutation	Effects on Pathology	Effects on Treatment
CRLF2 (locus Xp22.33)	Rearrangements and point mutations	JAK/STAT pathway activation	Use of JAK/STAT pathway inhibitor
IKZF1 (locus 7p12.2)	Rearrangements and point mutations	JAK/STAT pathway activation	Use of a JAK/STAT pathway inhibitor
NTRK3 (locus 15q25.3)	Fusion with ETV6	Activation of the TRK pathway	Use of a TRK inhibitor