Table 2.
Regulatory genes affecting the rat uterine-placental interface.
| Genes | Mutation | Phenotype | References |
|---|---|---|---|
| Fosl1 | Trophoblast-LOF a | Inhibition of endovascular trophoblast cell invasion | [178] |
| Kdm3a | Trophoblast-LOF | Disruption of hypoxia-activated endovascular trophoblast cell invasion | [64] |
| Mmp12 | Global-LOF | Disruption of hypoxia-activated endovascular trophoblast cell invasion | [64] |
| Ascl2 | Global-LOF | Junctional zone dysgenesis and failed intrauterine trophoblast cell invasion | [176] |
| Ahr | Global-LOF | Maternal AHR regulates TCDD-induced endovascular trophoblast cell invasion | [125] |
| Tfpi | Trophoblast-LOF | Inhibition of endovascular and interstitial trophoblast cell invasion | [48] |
a LOF, loss of function.