Table 1.
Zoometric and serum biochemical parameters (mean ± standard deviation) of non-diabetic rats (NDR); diabetic rats (DR); and DR treated with hydroxytyrosol 5 mg/kg/day p.o. (HT-5), 3′,4′-dihidroxifenilglicol (DHPG) 0.5 or 1 mg/kg/day p.o. (DHPG-0.5, DHPG-1), or their associations. N = 10 rats per group.
| Parameter | NDR | DR | HT-5 | DHPG-0.5 | DHPG-1 | HT-5+DHPG-0.5 | HT-5+DHPG-1 |
|---|---|---|---|---|---|---|---|
| Body weight (g) | 448 ± 8.0 | 340 ± 19.2 (+) | 345 ± 17.9 | 351 ± 20.0 | 344 ± 15.7 | 350 ± 22.3 | 349 ± 21.4 |
| Chow intake (g/day) | 20.2 ± 1.8 | 31.2 ± 3.8 (+) | 29.4 ± 2.2 | 30.8 ± 3.5 | 29.9 ± 3.0 | 28.7 ± 2.7 | 30.0 ± 3.9 |
| Water intake (mL/day) | 37.3 ± 4.8 | 111 ± 9.5 (+) | 90.2 ± 15.8 | 92.1 ± 16.0 | 95.5 ± 14.6 | 99.1 ± 16.3 | 100 ± 19.3 |
| Blood glucose (mg/dL) | 98.3 ± 4.8 | 387 ± 11.2 (+) | 370 ± 14.2 | 369 ± 13.0 | 377 ± 15.5 | 380 ± 16.8 | 381 ± 10.9 |
| Total cholesterol (mg/dL) | 60.0 ± 8.1 | 71.2 ± 5.8 | 70.0 ± 5.3 | 75.8 ± 6.4 | 69.7 ± 8.4 | 72.3 ± 8.5 | 71.1 ± 7.8 |
| LDL cholesterol (mg/dL) | 22.2 ± 5.0 | 31.1 ± 6.7 | 29.8 ± 8.1 | 30.5 ± 7.0 | 30.6 ± 7.4 | 28.9 ± 8.2 | 28.3 ± 5.9 |
| HDL cholesterol (mg/dL) | 19.6 ± 2.9 | 18.0 ± 5.1 | 27.6 ± 6.4 (*) | 23.4 ± 6.6 | 21.0 ± 5.2 | 24.5 ± 4.1 | 21.8 ± 4.8 |
| Triglycerides (mg/dL) | 71.4 ± 8.1 | 110 ± 12.8 (+) | 108 ± 11.4 | 106 ± 12.7 | 110 ± 14.9 | 84.4 ± 8.5 (*,a) | 104 ± 9.8 |
LDL: low density lipoproteins. HDL: high density lipoproteins. + p < 0.05 with respect to NDR; * p < 0.05 with respect to DR; a p < 0.05 with respect to HT-5, DHPG-0.5 and DHPG-1.