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. 2022 Feb 24;13(3):402. doi: 10.3390/genes13030402

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Brk moderates cell responses to chemotherapeutic agents. Brk levels were suppressed in T47D and GI101 cells by RNAi (Brk KD) and suppression was confirmed by Western blotting (A); the cells were seeded and allowed to adhere overnight in 96-well plates. Cells were treated with either doxorubicin (B,D) or Paclitaxel (C,E) for 72 h. Cell viability was determined by MTT assay and expressed as a percentage of the control (vehicle only) wells. The mean % survival (+/− SD) of a representative experiment is plotted with the control (transfected with no-target siRNA) in open diamonds and Brk-suppressed cells in closed squares; * indicates p < 0.05.