Table 1.

Known pathogenic genes associated with central precocious puberty.

Gene	Location	Protein	Biological Function
KISS1	1q32	Kisspeptin	KISS1/KISS1R system plays a crucial role in the central regulation of the gonadotropic axis at puberty.
KISS1R	19p13.3	KISS1R
MKRN3	15q11-q13	MKRN3	MKRN3 is a ubiquitin E3 ligase that promotes the ubiquitination of target proteins.
DLK1	14q32	Delta-like homolog 1	DLK1 is involved in the differentiation of several cell types including pituitary cell and adipocyte.