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The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 eliminates the antidepressant-like effect of the BDNF mimetic GSB-106 in the forced swimming test and does not affect the effect of amitriptyline. The results are presented as means ± SEM. Statistical analysis: two-way ANOVA (Tukey’s post hoc test); n = 10 mice per group.
