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Post-receptor signaling pathways activation patterns by NGF and BDNF dipeptide mimetic in in vitro studies.
| Neurotrophins Mimetics | Dipeptide Code | Basis Hairpin Loop | Activation of Trk Receptor and Post-Receptor Signaling Pathways |
|---|---|---|---|
| NGF mimetics | GK-6 | 1st | TrkA, PI3K/AKT, MAPK/ERK, PLCγ [23,31] |
| GK-2 | 4th | TrkA, PI3K/AKT, PLCγ [23,31] | |
| BDNF mimetics | GSB-214 | 1st | TrkB, PI3K/AKT, PLCγ [30,31] |
| GTS-201 | 2nd | TrkB, MAPK/ERK, PLCγ [29,31] | |
| GSB-106 | 4th | TrkB, PI3K/AKT, MAPK/ERK, PLCγ [30,31] |
