Table 2.
NGF and BDNF dipeptide mimetics activity in the forced swim test in BALB/c mice at acute administration.
| Group | Dose, mg/kg, i.p. |
Immobility Time, s 1 | Immobility Time, % of Control |
|---|---|---|---|
| Control | 0 | 220.8 ± 13.8 | 100 |
| GSB-106 | 0.1 | 169.4 ± 8.2 * | 76.7 |
| GSB-106 | 1.0 | 177.0 ± 11.2 * | 80.2 |
| Amitriptyline | 10.0 | 159.2 ± 9.8 * | 72.1 |
| Control | 0 | 226.1 ± 6.7 | 100 |
| GSB-214 | 0.1 | 223.8 ± 8.5 | 98.9 |
| GSB-214 | 1.0 | 230.9 ± 7.5 | 102.1 |
| Control | 0 | 228.5 ± 9.7 | 100 |
| GTS-201 | 0.1 | 241.3 ± 11.3 | 105.6 |
| GTS-201 | 1.0 | 209.8 ± 10.0 | 91.8 |
| GTS-201 | 5.0 | 228.1 ± 9.3 | 99.8 |
| Control | 0 | 214.4 ± 15.3 | 100 |
| GK-2 | 0.5 | 234.8 ± 9.5 | 105.1 |
| GK-2 | 1.0 | 225.3 ± 4.7 | 111.3 |
| Control | 0 | 204.1 ± 15.9 | 100 |
| GK-6 | 1.0 | 216.8 ± 13.1 | 106.2 |
| GK-6 | 2.0 | 176.9 ± 18.0 | 86.7 |
| GK-6 | 5.0 | 202.6 ± 9.5 | 99.3 |
| Amitriptyline | 10.0 | 133.2 ± 10.4 * | 65.3 |
1 Data are expressed as means ± standard error of mean (SEM). * p < 0.05 compared to the control group (one-way ANOVA (Dunnett’s post hoc test)). n = 7–10 mice per group.