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. 2022 Mar 14;23(6):3123. doi: 10.3390/ijms23063123

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inhibitory effect of ZO on I_Na on mHippoE-14 hippocampal neurons. (A) Representative current traces obtained in the absence (a) or presence of 1 μM ZO (b). The inset shows the pulse protocol used in this study. Panel (B,C) are summary bar graphs demonstrating the effects of ZO and ZO plus Tef on the peak amplitude or τ_inact(S) of depolarization-activated I_Na, respectively (mean ± SEM; n = 7 for each bar). * Significantly different from the control (p < 0.05), ** significantly different from the 1 μM ZO-alone group (p < 0.05), and + significantly different from the 3 μM ZO-alone group (p < 0.05). Panel (A): (One-way ANOVA, F(3,24) = 3.351, p = 0.03) and panel (B): (One-way ANOVA, F(3,24) = 4.012, p = 0.02).