Table 2.
Dimensions (thickness and weight), drug content, surface pH, folding endurance, and in vitro disintegration time for the vardenafil ODFs (data presented as the mean ± SD).
| Formulation Symbol | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|
| Thickness (µm) |
400 ± 5.0 | 380 ± 4.5 | 390 ± 3.5 | 385 ± 5.8 | 360 ± 8.5 | 365 ± 8.5 | 340 ± 3.0 | 350 ± 3.5 |
| Weight (mg) |
31.5 ± 0.3 | 38.5 ± 3.3 | 37.5 ± 2.3 | 38 ± 2.5 | 36 ± 3.4 | 37 ± 2.7 | 38 ± 2.8 | 38 ± 1.45 |
| Drug content (mg) |
9.5 ± 0.5 | 9.0 ± 0.2 | 9.8 ± 0.6 | 8.9 ± 0.5 | 9.0 ± 0.3 | 9.4 ± 0.4 | 10 ± 0.3 | 9.5 ± 0.2 |
| Surface pH | 7.5 | 7.0 | 7.0 | 7.5 | 7.5 | 7.0 | 7.0 | 7.0 |
| Folding endurance | 10 ± 2.4 | 15 ± 2.0 | 12 ± 2.5 | 20 ± 2.6 | 10 ± 2.1 | 16 ± 2.0 | 12 ± 2.5 | 14 ± 2.0 |
| In vitro disintegration time (min) | 16 ± 2.5 | 11.0 ± 2.1 | 11 ±1.5 | 8.0 ± 1.0 | 7.0 ± 1.0 | 5.0 ± 1.0 | 3.0 ± 1.5 | 2.0 ± 1.0 |