Table 3.
Examples of HDACs inhibitors in clinical trials of diseases of CNS and PNS (from https://clinicaltrials.gov/) (Accessed on 18 February 2022).
| Compound | Disease | Phase | Status |
|---|---|---|---|
| Vorinostat (pan inhibitor) | Alzheimer’s disease | Phase 1 | Recruiting |
| CKD-504 | Huntington disease | Unknown | Unknown |
| Nicotinamide (HDACi3) | Friedreich’s ataxia | Phase 0 | Not recruiting yet |
| Vorinostat (pan inhibitor) | Niemann–Pick Disease | Phase 1/2 | Completed |
| Ricolinostat (hDACi6) | Painful diabetic neuropathy | Phase 2 | Recruiting |
| AR-42 (OSU-HDAC42) | Vestibular Schwannoma Neurofibromatosis Type 2 |
Early Phase 1 | Active, not recruiting |
| REC-2228 (OSU-HDAC42) | Neurofibromatosis Type 2 | Phase 2/3 | Not yet recruiting |