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. 2022 Mar 18;23(6):3314. doi: 10.3390/ijms23063314

Table 1.

Association of cancer cell matrix metalloproteinase 8 (MMP-8) expression in cancer cells, the number of tumour-associated MMP-8 positive polymorphonuclear cells (PMNs) and the plasma C-reactive protein (CRP) level with clinicopathological characteristics.

Cancer Cell
MMP-8
p Value PMNs p Value CRP Levels p Value
Negative (0) Positive
(1–3)
Negative (0) Positive
(1–3)
Low
(<10 mg/L)
High
(≥10 mg/L)
n (%) 12 (8.5) 129 (86.5) 59 (41.8) 82 (58.2) 97 (78.2) 27 (21.8)
Age, in years 0.208 0.135 0.107
<65 5 (7.2) 64 (92.8) 29 (42.0) 40 (58.0) 50 (82.0) 11 (18.0)
≥65 7 (9.7) 65 (90.3) 30 (41.7) 42 (58.3) 47 (74.6) 16 (25.4)
Sex 0.168 0.001 0.170
Male 8 (10.4) 69 (89.6) 41 (53.2) 36 (46.8) 55 (77.5) 16 (22.5)
Female 4 (6.3) 60 (93.8) 18 (28.1) 46 (71.9) 42 (79.2) 11 (20.8)
T1 1 (7.1) 13 (92.9) 0.171 2 (14.3) 12 (85.7) 0.036 12 (100.0) 0 (0.0)
T2 7 (7.6) 85 (92.4) 41 (44.6) 51 (55.4) 63 (78.8) 17 (21.2)
T3 4 (11.4) 31 (88.6) 16 (45.7) 19 (54.3) 22 (68.8) 10 (31.2)
N0 4 (9.8) 37 (90.2) 0.163 10 (24.4) 31 (75.6) 0.003 28 (84.8) 5 (15.2)
N1 5 (7.5) 62 (92.5) 31 (46.3) 36 (53.7) 43 (72.9) 16 (27.1)
N2 3 (9.1) 30 (90.9) 18 (54.5) 15 (45.5) 26 (81.3) 6 (18.7)
Grade 0.094 0.113
1 0 (0.0) 15 (100.0) 6 (40.0) 9 (60.0) 9 (75.0) 3 (25.0)
2 8 (8.9) 82 (91.9) 37 (41.1) 53 (58.9) 61 (76.3) 19 (23.7)
3 3 (13.0) 20 (87.0) 11 (47.8) 12 (52.2) 17 (81.0) 4 (19.0)
Perineural invasion 0.249 0.088
No 4 (9.1) 40 (90.9) 16 (36.4) 28 (63.6)
Yes 8 (8.7) 84 (91.3) 42 (45.7) 50 (54.3)
Perivascular invasion 0.266 0.010
No 9 (9.0) 91 (91.0) 37 (37.0) 63 (63.0)
Yes 3 (8.1) 34 (91.9) 22 (59.5) 15 (40.5)
ASA score 0.190 0.102
1 0 (0.0) 3 (100.0) 0 (0.0) 3 (100.0) 2 (66.7) 1 (33.3)
2 5 (12.2) 36 (87.8) 18 (43.9) 23 (56.1) 33 (84.6) 6 (15.4)
3 5 (9.8) 46 (90.2) 23 (45.1) 28 (54.9) 31 (68.9) 14 (31.1)
4 1 (20.0) 4 (80.0) 2 (40.0) 3 (60.0) 3 (75.0) 1 (25.0)
CRP 0.011 0.102
<10 mg/L 5 (5.2) 92 (94.8) 36 (37.1) 61 (62.9)
≥10 mg/L 6 (22.2) 21 (77.8) 13 (48.1) 14 (51.9)