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. 2022 Mar 10;14(3):606. doi: 10.3390/pharmaceutics14030606

Table 3.

The half maximal lethal concentration (LC50) values estimated after 7 days incubation of C. elegans nematodes with free αM and V, or their dendrimer conjugates. Data are presented as medians with the first and third quartile. Presented values were calculated with AAT Bioquest IC50 calculator [46].

LC50 [μM] 1st Quartile 3rd Quartile
α-Mangostin [2] 18.74 18.64 20.23
G3gh2B5M >16 >16 >16
G32B12gh5M [29] 7.87 4.95 8.09
Vadimezan >>200 >>200 >>200
G3gh4B5V >>24 >>24 >>24’
G32B12gh5V >>12 >>12 >>12