Eight weeks of exercise significantly improves body composition and reverses the detrimental effects of an HFD in oxygen consumption. (A) Total distance run, (B) Body weight, (C) Total lean mass, (D) Total fat mass, (E) Bone mass normalized to lean mass, (F) Oxygen consumption (VO2), (G) Carbon dioxide production (VCO2), and (H) Respiratory Exchange Ratio. N = 7–15 per group). T-test or one or two-way ANOVA were used with Tukey’s multiple comparison test (** p < 0.01, *** p < 0.001, **** p < 0.0001 LFPD vs. HFD, § p < 0.05, §§ p < 0.01, §§§
p < 0.001 §§§§ p < 0.0001 HPD vs. HFD, # p < 0.05 LFPD vs. HPD, € p < 0.05, €€ p < 0.01, €€€€ p < 0.0001 Sedentary vs. Exercise). Data are expressed as the mean ± SEM. Box and whisker plot is shown as min to max with median.