Table 2.
Percent inhibition of CHJ series compounds (10 μM) on SphK1.
| Code | Structure | SphK1 (%Inhibition) | Code | Structure | SphK1 (%Inhibition) |
|---|---|---|---|---|---|
|
SAMS10
(lead comd) |
|
60 |
CHJ
04036 |
|
12 |
|
CHJ
02029 |
|
1 |
CHJ
04058 |
|
27 |
|
CHJ
02049 |
|
4 |
CHJ
04059 |
|
3 |
|
CHJ
02050 |
|
0 |
CHJ
04060 |
|
28 |
|
CHJ
03001 |
|
0 |
CHJ
04061 |
|
19 |
|
CHJ
03003 |
|
4 |
CHJ
04064 |
|
7 |
|
CHJ
03004 |
|
4 |
CHJ
04065 |
|
0 |
|
CHJ
03005 |
|
10 |
CHJ
04066 |
|
0 |
|
CHJ
03011 |
|
21 |
CHJ
04068 |
|
16 |
|
CHJ
03012 |
|
19 |
CHJ
04072 |
|
20 |
|
CHJ
03014 |
|
20 |
CHJ
04082 |
|
32 |
|
CHJ
03015 |
|
4 |
CHJ
04083 |
|
32 |
|
CHJ
03017 |
|
0 |
CHJ
04084 |
|
24 |
|
CHJ
03018 |
|
0 |
CHJ
04085 |
|
11 |
|
CHJ
03043 |
|
0 |
CHJ
04086 |
|
7 |
|
CHJ
04010 |
|
0 |
CHJ
04089 |
|
17 |
|
CHJ
04011 |
|
5 |
CHJ
04090 |
|
2 |
|
CHJ
04012 |
|
2 |
CHJ
04091 |
|
7 |
|
CHJ
04020 |
|
24 |
CHJ
04092 |
|
16 |
|
CHJ
04022 |
|
30 |
CHJ
04093 |
|
11 |
|
CHJ
04023 |
|
20 |
CHJ
04094 |
|
0 |
|
CHJ
04024 |
|
18 |
CHJ
04097 |
|
6 |
|
CHJ
04025 |
|
10 |
CHJ
04099 |
|
16 |
|
CHJ
04026 |
|
4 |
CHJ
05001 |
|
23 |
|
CHJ
04027 |
|
11 |
CHJ
05002 |
|
26 |
|
CHJ
04033 |
|
3 |
CHJ
05003 |
|
17 |
|
CHJ
04034 |
|
11 | PF-543 a | - | 49 ± 2.1 n M |
a PF-543 is a positive control. IC50 values were calculated from three independent experiments.