Table 3.
In vitro inhibitory activities of CHJ series compounds against the selected cancer cells.
| Code | IC50 (μM) a | |||
|---|---|---|---|---|
| A549 | SKOV3 | A375 | LOVO | |
| SAMS10 | 14.64 ± 0.06 | 21.07 ± 0.18 | 27.11 ± 0.66 | 11.48 ± 0.07 |
| CHJ02029 | 3.55 ± 0.06 | 6.30 ± 0.16 | 2.43 ± 0.12 | 1.87 ± 0.02 |
| CHJ02049 | 0.52 ± 0.23 | 0.62 ± 0.08 | 0.62 ± 0.04 | 1.25 ± 0.03 |
| CHJ02050 | 1.09 ± 0.55 | 4.04 ± 0.06 | 1.87 ± 0.07 | 3.88 ± 1.80 |
| CHJ03001 | 1.30 ± 0.43 | 2.48 ± 0.63 | 1.95 ± 0.33 | 1.26 ± 0.53 |
| CHJ03003 | 6.08 ± 0.90 | 3.00 ± 0.99 | 5.95 ± 0.42 | 0.70 ± 0.26 |
| CHJ03004 | 2.10 ± 1.25 | 6.19 ± 0.25 | 0.72 ± 0.80 | 2.54 ± 0.10 |
| CHJ03005 | 15.58 ± 0.16 | 3.99 ± 0.21 | 5.60 ± 0.81 | 6.66 ± 0.11 |
| CHJ03011 | 10.56 ± 0.02 | 21.21 ± 1.08 | 1.82 ± 1.23 | 15.19 ± 1.78 |
| CHJ03012 | 2.19 ± 1.04 | 3.54 ± 1.02 | 0.16 ± 0.33 | 1.95 ± 0.43 |
| CHJ03014 | 1.09 ± 0.06 | 6.19 ± 0.62 | 1.63 ± 0.72 | 0.53 ± 0.15 |
| CHJ03015 | 1.03 ± 0.13 | 4.47 ± 1.62 | 3.22 ± 0.42 | 0.55 ± 0.21 |
| CHJ03017 | 17.25 ± 0.79 | 6.21 ± 1.04 | 8.68 ± 0.11 | 2.44 ± 0.03 |
| CHJ03018 | 18.76 ± 1.06 | 1.79 ± 0.23 | 3.13 ± 0.06 | 1.72 ± 0.58 |
| CHJ03043 | 2.50 ± 1.32 | 2.90 ± 0.19 | 0.54 ± 0.26 | 0.95 ± 0.41 |
| CHJ04010 | 4.51 ± 1.29 | 4.96 ± 1.26 | 0.45 ± 0.46 | 2.78 ± 0.23 |
| CHJ04011 | 4.05 ± 1.12 | 2.41 ± 1.03 | 0.48 ± 0.28 | 1.01 ± 0.08 |
| CHJ04012 | 6.38 ± 0.07 | 4.34 ± 0.32 | 1.24 ± 1.01 | 2.12 ± 0.04 |
| CHJ04020 | 1.38 ± 1.14 | 3.40 ± 1.17 | 1.60 ± 0.92 | 3.83 ± 1.80 |
| CHJ04022 | 1.88 ± 0.19 | 1.03 ± 0.24 | 0.05 ± 0.01 | 0.69 ± 0.03 |
| CHJ04023 | 5.44 ± 2.54 | 8.03 ± 2.77 | 0.81 ± 0.33 | 3.07 ± 1.62 |
| CHJ04024 | 5.45 ± 1.03 | 1.37 ± 0.34 | 0.98 ± 0.76 | 18.61 ± 3.22 |
| CHJ04025 | 4.21 ± 2.24 | 3.32 ± 1.02 | 2.34 ± 1.63 | 2.55 ± 1.65 |
| CHJ04026 | 0.97 ± 0.21 | 7.45 ± 2.26 | 1.50 ± 0.06 | 0.82 ± 0.42 |
| CHJ04027 | 6.22 ± 1.34 | 3.02 ± 1.76 | 0.73 ± 0.13 | 2.35 ± 1.04 |
| CHJ04033 | 0.95 ± 0.37 | 6.22 ± 3.05 | 0.92 ± 0.07 | 2.23 ± 1.26 |
| CHJ04034 | 0.86 ± 0.45 | 3.06 ± 1.10 | 0.65 ± 0.14 | 1.16 ± 0.94 |
| CHJ04036 | 17.84 ± 3.62 | 15.5 ± 2.56 | 18.36 ± 1.10 | 3.67 ± 0.41 |
| CHJ04058 | 245.31 ± 2.40 | 101.71 ± 1.48 | 56.21 ± 0.55 | 53.96 ± 2.14 |
| CHJ04059 | 10.63 ± 3.37 | 3.26 ± 1.21 | 3.23 ± 0.49 | 3.92 ± 0.56 |
| CHJ04061 | 333.10 ± 2.7 | 143.47 ± 3.1 | 62.13 ± 4.21 | 97.14 ± 4.21 |
| CHJ04064 | 21.50 ± 3.65 | 17.05 ± 0.24 | 9.24 ± 2.65 | 3.55 ± 2.14 |
| CHJ04065 | 25.48 ± 2.11 | 27.07 ± 1.62 | 10.82 ± 1.79 | 3.14 ± 1.06 |
| CHJ04066 | 29.90 ± 2.45 | 77.07 ± 4.07 | 10.29 ± 1.40 | 2.50 ± 0.65 |
| CHJ04068 | 5.46 ± 1.76 | 4.21 ± 1.23 | 1.54 ± 1.34 | 0.52 ± 0.40 |
| CHJ04072 | 12.53 ± 2.44 | 9.62 ± 4.23 | 2.26 ± 0.37 | 5.21 ± 2.31 |
| CHJ04082 | 22.26 ± 1.98 | 28.54 ± 5.22 | 7.51 ± 2.62 | 2.82 ± 1.05 |
| CHJ04083 | 13.35 ± 2.02 | 10.36 ± 1.43 | 2.44 ± 1.03 | 1.23 ± 0.17 |
| CHJ04084 | 42.69 ± 3.06 | 96.38 ± 2.72 | 16.70 ± 2.48 | 7.54 ± 1.02 |
| CHJ04085 | 28.83 ± 5.12 | 49.22 ± 1.97 | 7.32 ± 1.80 | 1.94 ± 0.79 |
| CHJ04089 | 27.78 ± 1.73 | 42.71 ± 2.61 | 15.03 ± 2.37 | 49.50 ± 3.54 |
| CHJ04090 | 35.01 ± 2.21 | 36.4 ± 2.17 | 11.70 ± 2.12 | 34.05 ± 2.59 |
| CHJ04091 | 11.05 ± 1.33 | 17.8 ± 3.11 | 4.01 ± 3.11 | 10.63 ± 3.20 |
| CHJ04092 | 30.16 ± 2.76 | 34.5 ± 2.70 | 11.23 ± 1.05 | 47.91 ± 3.43 |
| CHJ04093 | 20.12 ± 2.01 | 10.24 ± 1.69 | 2.60 ± 1.22 | 14.45 ± 2.14 |
| CHJ04094 | 18.40 ± 3.17 | 15.86 ± 2.11 | 2.05 ± 1.01 | 28.51 ± 4.42 |
| CHJ04097 | 24.38 ± 2.78 | 33.59 ± 2.47 | 14.85 ± 2.77 | 32.10 ± 3.39 |
| CHJ04099 | 23.10 ± 2.58 | 37.39 ± 2.48 | 16.16 ± 2.11 | 38.24 ± 2.94 |
| CHJ05001 | 30.69 ± 3.12 | 40.12 ± 3.02 | 15.78 ± 1.73 | 49.10 ± 2.71 |
| CHJ05002 | 35.66 ± 2.71 | 42.96 ± 2.37 | 13.66 ± 2.06 | 33.10 ± 3.27 |
| CHJ05003 | 33.97 ± 2.11 | 35.11 ± 1.35 | 24.92 ± 1.93 | 52.49 ± 1.22 |
| Cisplatin | 4.21 ± 1.31 | 1.91 ± 0.43 | 5.91 ± 1.64 | 2.64 ± 1.12 |
a IC50 values were calculated from three independent experiments using the MTT assay. The values are reported as the mean ± SD.