TABLE 2.
Susceptibilities of strains to Fqs and efflux pump substrates
| Strain | MIC (μg/ml)a
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cp | Cp + RS | CP/CIP + RS | NOR | NOR + RS | NOR/NOR + RS | EBR | EBR + RS | EBR/EBR + RS | ACR | ACR + RS | ACR/ACR + RS | |
| S. pneumoniae R6 | 0.5 | 0.5 | 1 | 4 | 4 | 1 | 2 | 0.5 | 4 | 4 | 2 | 2 |
| S. oralis NCTC 11427 | 2 | 1 | 2 | 16 | 4 | 4 | 16 | 1 | 16 | 8 | 1 | 8 |
| S. oralis ATCC 10557 | 2 | 1 | 2 | 16 | 4 | 4 | 16 | 1 | 16 | 8 | 2 | 4 |
| S. mitis NCTC 12261 | 1 | 0.5 | 2 | 8 | 2 | 4 | 16 | 1 | 16 | 16 | 2 | 8 |
| S. mitis V1b | 4 | 1 | 4 | 16 | 2 | 8 | 32 | 0.25 | 128 | 8 | 0.5 | 16 |
| S. mitis V2 | 4 | 1 | 4 | 32 | 4 | 8 | 32 | 1 | 32 | 8 | 1 | 8 |
| S. mitis V3 | 4 | 1 | 4 | 32 | 4 | 8 | 32 | 1 | 32 | 16 | 2 | 8 |
| S. mitis V4 | 4 | 1 | 4 | 32 | 4 | 8 | 32 | 1 | 32 | 16 | 0.5 | 32 |
| S. sanguis V5 | 4 | 1 | 4 | 32 | 4 | 8 | 32 | 0.5 | 64 | 8 | 0.5 | 16 |
| S. mitis V6 | 4 | 1 | 4 | 32 | 4 | 8 | 32 | 0.5 | 64 | 16 | 0.5 | 32 |
| S. mitis V10 | 4 | 4 | 1 | 32 | 16 | 2 | 8 | 2 | 4 | 4 | 2 | 2 |
| S. mitis V8 | 16 | 4 | 4 | 128 | 16 | 8 | 32 | 1 | 32 | 16 | 1 | 16 |
| S. oralis V9 | 32 | 4 | 8 | 256 | 16 | 16 | 64 | 1 | 64 | 16 | 1 | 16 |
a
RS, reserpine; NOR, norfloxacin; EBR, ethidium bromide; ACR, acriflavine. MICs are the averages of at least two determinations, which did not differ by more than a twofold dilution.
b
Classification of the VGS clinical isolates to the species level was done with the API 20-Strep and ID 32-Strep systems.