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. 2022 Mar 15;27(6):1904. doi: 10.3390/molecules27061904

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Differential metabolite analysis and MSEA. (A) Volcano plot of significantly different metabolites. Red represents a significant increase in abundance, green represents a significant decrease in abundance, and black represents no significant change in abundance. The size of dots represents the VIP of metabolites. (B) Volcano plot of metabolite set enrichment analysis (MSEA) on basis of the Reactome database. Red and blue represent pathways mainly enriched by metabolites with increased or decreased abundance, respectively. Black represents pathways enriched by metabolites with no significant alteration. For visualization purposes, −log10 (p-value) greater than 6 was defined as equal to 6. (C) Enrichment plots for top five pathways mainly composed of metabolites with increased or decreased abundance based on the p-value.