Table 2.
Metabolite set enrichment analysis based on the Reactome database.
| Pathway Name | p-Value | NES | Size |
|---|---|---|---|
| Adaptive Immune System | 0.039127 | −1.399622 | 2 |
| Aflatoxin activation and detoxification | 0.046795 | 1.316706 | 1 |
| Aspartate and asparagine metabolism | 0.033776 | 1.490742 | 4 |
| Biosynthesis of DHA-derived sulfido conjugates | 0.046795 | 1.316706 | 1 |
| Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | 0.046795 | 1.316706 | 1 |
| Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) | 0.046795 | 1.316706 | 1 |
| C-type lectin receptors (CLRs) | 0.039127 | −1.399622 | 2 |
| CLEC7A (Dectin-1) signaling | 0.039127 | −1.399622 | 2 |
| Cytokine Signaling in Immune system | 0.007981 | −1.639997 | 4 |
| DAG and IP3 signaling | 0.039127 | −1.399622 | 2 |
| ERK1/ERK2 pathway | 0.014242 | −1.575384 | 3 |
| Fc epsilon receptor (FCERI) mediated NF-κB activation | 0.039127 | −1.399622 | 2 |
| FLT3 Signaling | 0.007981 | −1.639997 | 4 |
| FCERI signaling | 0.039127 | −1.399622 | 2 |
| Gamma carboxylation, hypusine formation, and arylsulfatase activation | 0.034649 | −1.505648 | 4 |
| Glycerophospholipid biosynthesis | 0.027534 | 1.563377 | 11 |
| Histidine catabolism | 0.018443 | −1.610865 | 5 |
| MAPK family signaling cascades | 0.014242 | −1.575384 | 3 |
| Metabolism | 0.015173 | −1.465771 | 109 |
| Nucleobase catabolism | 0.004696 | −1.825806 | 22 |
| Nucleotide metabolism | 0.007471 | −1.804005 | 24 |
| Nucleotide salvage | 0.000174 | −2.036357 | 17 |
| Phenylalanine and tyrosine metabolism | 0.009249 | 1.590928 | 4 |
| Purine salvage | 0.001607 | −1.851134 | 8 |
| Pyrimidine catabolism | 0.014483 | −1.661637 | 11 |
| Pyrimidine salvage | 0.004541 | −1.800858 | 9 |
| Pyruvate metabolism | 0.019494 | 1.606548 | 5 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 0.012356 | 1.706404 | 6 |
| RAF/MAP kinase cascade | 0.014242 | −1.575384 | 3 |
| RAS processing | 0.014242 | −1.575384 | 3 |
| SLC-mediated transmembrane transport | 0.036751 | −1.512534 | 40 |
| Synthesis of diphthamide-EEF2 | 0.034649 | −1.505648 | 4 |
| The citric acid (TCA) cycle and respiratory electron transport | 0.004119 | 1.757392 | 7 |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | 0.002303 | −1.831755 | 11 |
| Transport of small molecules | 0.025099 | −1.574603 | 45 |
| Transport of vitamins, nucleosides, and related molecules | 0.010163 | −1.765573 | 24 |
NES = normalized enrichment score; DAG = diacylgycerol; IP = inositol triphosphate; ERK = extracellular signal-regulated kinase; NF-κB = nuclear factor κB; FLT = fms-like tyrosine kinase; MAPK = mitogen-activated protein kinase; RAF = rapidly accelerated fibrosarcoma; MAP = mitogen-activated protein; RAS = rat sarcoma virus; SLC = solute carrier; EEF = Eukaryotic elongation factor.