Table 1.
Association of the rs1260326 genotypes with metabolic and hematological phenotypes.
| Clinical and Laboratory Parameters | Total | β | SE | p Value * |
|---|---|---|---|---|
| Anthropology | ||||
| Age (years) | 51.0 (41.0–59.0) | 0.0767 | 0.0530 | 0.1481 |
| Waist circumference (cm) | 83.0 (76.0–89.5) | 0.0533 | 0.0253 | 0.0350 |
| Waist–hip ratio | 0.87 ± 0.07 | 0.0002 | 0.0003 | 0.3493 |
| Body mass index (kg/m2) | 23.8 (21.6–26.3) | −0.0318 | 0.0180 | 0.0773 |
| Blood pressure | ||||
| Systolic BP * (mmHg) | 115.0(105.0–127.0) | 0.3931 | 0.0762 | 2.48 × 10−7 |
| Diastolic BP * (mmHg) | 71.0 (65.0–79.0) | 0.2182 | 0.0497 | 1.10 × 10−5 |
| Mean BP * (mmHg) | 86.0 (78.7–94.3) | 0.2765 | 0.0546 | 4.08 × 10−7 |
| Lipid profiles | ||||
| Total cholesterol # (mg/dL) | 171.0 (193.0–216.0) | 0.0052 | 0.0004 | 1.74 × 10−39 |
| HDL cholesterol # (mg/dL) | 53.0 (45.0–63.0) | −0.0003 | 0.0005 | 0.5755 |
| LDL cholesterol # (mg/dL) | 119.0 (99.0–140.0) | 0.0047 | 0.0006 | 1.90 × 10−15 |
| Triglyceride # (mg/dL) | 90.0 (63.0–132.0) | 0.0302 | 0.0011 | 7.34 × 10−168 |
| Glucose metabolism | ||||
| Fasting plasma glucose ** (mg/dL) | 92.0 (87.0–97.0) | −0.6133 | 0.0750 | 2.83 × 10−16 |
| HbA1C ** (%) | 5.6 (5.4–5.9) | −0.0038 | 0.0030 | 0.2031 |
| Uric acid | ||||
| Uric acid *** (mg/dL) | 5.2 (4.4–6.2) | 0.0714 | 0.0055 | 4.72 × 10−38 |
| Renal function | ||||
| Creatinine (mg/dL) | 0.68 (0.57–0.83) | −0.0072 | 0.0011 | 9.45 × 10−12 |
| eGFR (mL/min/1.73 m2) | 100.7 (87.5–116.4) | 1.1035 | 0.1074 | 9.07 × 10−25 |
| Urine albumin (mg/L) | 8.7 (5.4–15.2) | 0.0147 | 0.0023 | 9.64 × 10−11 |
| Liver function | ||||
| AST (U/L) | 23.0 (20.0–27.0) | 0.3812 | 0.0602 | 2.43 × 10−10 |
| ALT (U/L) | 19.0 (14.0–27.0) | 0.3921 | 0.0929 | 2.40 × 10−5 |
| γGT (U/L) | 17.0 (12.0–26.0) | 1.3605 | 0.1550 | 1.68 × 10−18 |
| Serum albumin (g/dL) | 4.5 (4.4–4.6) | 0.0182 | 0.0011 | 9.08 × 10−61 |
| Total bilirubin (mg/dL) | 0.6 (0.5–0.8) | 0.0022 | 0.0013 | 0.0968 |
| Hematological parameters | ||||
| Leukocyte count (103/μL) | 5.7 (4.7–6.8) | 0.0523 | 0.0076 | 8.17 × 10−12 |
| Hematocrit (%) | 41.6 (39.0–44.5) | −0.0387 | 0.0173 | 0.0256 |
| Platelet count (103/μL) | 237.0 (202.0–276.0) | 2.0649 | 0.2833 | 3.17 × 10−13 |
| Red blood cell count (106/μL) | 4.7 (4.4–5.0) | −0.0052 | 0.0022 | 0.0189 |
| Hemoglobin (g/dL) | 13.7 (12.8–14.8) | −0.0118 | 0.0061 | 0.0545 |
p: adjusted for age, BMI, and current smoking; Age: adjusted for BMI and current smoking; and BMI: adjusted for age and smoking. Participants were analyzed after the exclusion of those with a history of * hypertension, ** diabetes mellitus, *** gout, and # hyperlipidemia. Data are presented as median (interquartile range). Abbreviations: SE, standard error; BP, blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HbA1C, hemoglobin A1C; eGFR, estimated glomerular filtration rate; BUN, blood urea nitrogen; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γGT, γ-glutamyl transferase; BMI, body mass index.