Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
P2X7R modulation of β-cell pro-inflammatory functions. Hyperglycemia promotes eATP release and P2X7R-dependent K+ efflux and Ca2+ influx into the β-cells. Ca2+ overload promotes mitochondrial dysfunction, reactive oxygen species (ROS) generation, inhibition of ATP synthesis, and eventually triggers apoptosis. Moreover, intracellular K+ decrease induces the assembly of the NLRP3 inflammasome, promotes IL-1β release and further accelerates β-cell apoptosis.
