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. 2022 Feb 24;11(3):289. doi: 10.3390/pathogens11030289

Figure 1.

Figure 1

Structure of human HMGB1 and the complete HMGB1 protein sequence of Homo sapiens, S. japonicum and S. mansoni. (A) Human HMGB1 consists of 215 aa residues, which can be divided into the A box (aa 9–79), B box (aa 95–163), an acidic tail (aa 186–215), two NLSs (aa 28–44 and aa 179–185), a TLR binding site (aa 89–108), and a RAGE binding site (aa 150–183). (B) The complete protein sequence of H. sapiens HMGB1 (GenBank accession no. NP_002119) in relation to the orthologues of S. japonicum (DQ005528) and S. mansoni (DQ005529).