Table 1.
Gene nomenclature and function.
| Gene Nomenclature |
Gene Name | Principal Function |
|---|---|---|
| ADAMTS13 | ADAM Metallopeptidase with Thrombospondin Type 1 Motif 13 | von Willebrand factor cleavage |
| ALOX5 | Arachidonate 5-Lipoxygenase | Leukotriene biosynthesis |
| CD31 | Platelet And Endothelial Cell Adhesion Molecule 1 | Ig-like adhesion molecule Leukocyte migration, angiogenesis, integrin activation, immunomodulation, mechanotrasduction |
| CD44 | Hyaluronan receptor | Cell–cell interactions, cell adhesion and migration |
| EDN1 | Endothelin 1 | Vasoconstrictor |
| GPX1 | Glutathione peroxidase 1 | Redox-balancer |
| HYAL2 | Hyaluronidase 2 | Hyaluronan degradation |
| ICAM1 | Intercellular Adhesion Molecule 1 | Cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture |
| LGALS8 | Galectin 8 | Cell–cell adhesion, cell–matrix interaction, growth regulation, apoptosis, and RNA splicing |
| MMP1 | Matrix metalloproteinase 1 | ECM and molecule degradation |
| MMP2 | Matrix metalloproteinase 2 | ECM and molecule degradation; remodeling of the vasculature, angiogenesis, tissue repair, inflammation, and atherosclerotic plaque rupture |
| MMP9 | Matrix metalloproteinase 9 | ECM and molecule degradation; leukocyte migration |
| NOS3 | Endothelial nitric oxide synthase | Implication in vascular smooth muscle relaxation |
| PI16 | Peptidase Inhibitor 16 | Cardiomyocyte growth inhibition |
| PLA2G7 | Phospholipase A2 Group VII | Platelet-activating factor (PAF) activity modulation |
| SOD1 | Superoxide dismutase 1 | Superoxide anion radical destruction |
| TFRC | Transferrin Receptor | Cell surface receptor for cellular iron uptake |
| TIMP1 | TIMP Metallopeptidase Inhibitor 1 | Cell proliferation and potential an anti-apoptotic function |
| TNF | Tumor Necrosis Factor | Cell apoptosis, proliferation, differentiation, lipid metabolism, and coagulation. Multifunctional proinflammatory cytokine |
| VCAM1 | Vascular cell adhesion molecule 1 |
Cell–cell recognition, mediates leukocyte-endothelial cell adhesion |
| VEGFA | Vascular endothelial growth factor A |
Vascular endothelial cell proliferation and migration. Angiogenesis |