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. 2022 Mar 11;14(3):575. doi: 10.3390/v14030575

Figure 4.

Figure 4

The I226R protein inhibits VSV-induced expression of IFN-β and ISGs in swine cells: (A–D) 3D4/21 cells stably expressing I226R or EV were generated; then, they were infected with VSV (MOI = 1) for 12 h. RT-qPCR analysis was performed to examine the mRNA levels of IFN-β (A), IL29 (B), IFITM1 (C), and IFITM3 (D). (E,F) PK15 cells stably expressing I226R or EV were generated; then, they were infected with VSV (MOI = 1) for 12 h. RT-qPCR analysis was performed to detect the mRNA levels of IFN-β (E) and IFITM1 (F). All the results are expressed as the means ± standard deviation from three independent experiments. Statistical analysis was performed using the Student’s t-test. ** p < 0.01.