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. 2022 Mar 8;27(6):1763. doi: 10.3390/molecules27061763

Figure 5.

Figure 5

THC and CBD are not cytotoxic in PBMCs from HCs and pwMS. MTT assay of PBMCs from (a) HCs, and (b) pwMS treated (for 24 h) with THC (10 μM) alone, CBD (10 μM) alone and THC:CBD in a 1:1 combination (10 μM:10 μM). The number of control cells, i.e., viable cells exposed to vehicle (0.1% ethanol), was defined as 100% in each participant. Triton X-100 (0.2% for 10 min) treatment was used as a positive control. Kruskal–Wallis statistic = 54.5 in HC samples. Kruskal–Wallis statistic = 25.1 in MS samples. Data are presented as median viability values expressed as % control, minimum and maximum values and IQR. Symbols indicate individual data points in PBMCs from 20 HCs and 12 pwMS. Statistical significance was determined by Kruskal–Wallis tests, with Dunn’s multiple comparison post-hoc test. ** p < 0.01, *** p < 0.001 vs. vehicle control group.