Table 1.
Loss of HELQ partially suppresses the number of lethal flanking deletions that occur in the absence of BLM. The P{wa} construct is inserted in an intron of scalloped (sd), an X chromosome gene required for viability. F1 females inheriting an aborted SDSA repair event with a flanking deletion sometimes have malformed wings (left column), while males inheriting large deletions into the sd coding sequence do not survive (right column). Parenthetical numbers indicate the total number of events analyzed: left, total number of yellow-eyed F1 females counted; right, total number of independent yellow-eyed F1 females from which F2 males were counted. a: significantly increased from WT (P < 0.0001); b: significantly different from both single mutants (P < 0.0001); Fisher’s exact test.
| Genotype | % Scalloped-Winged Females (F1) | % Male-Lethal Deletions (F2) |
|---|---|---|
| Wild type | 0.0% (84) | 0.0% (44) |
| helq 288A | 0.2% (1061) | 2.0% (246) |
| blmN 1 | 17.3% (623) a | 55.3% (159) a |
| helq 288A , blmN 1 | 3.9% (332) b | 25.2% (127) a,b |