Table 3.
Association of 16S RMTases, carbapenemases, sequence types, and plasmid incompatibility groups among pan-aminoglycoside- and carbapenem-resistant K. pneumoniae.
| K. pneumoniae (n = 75) | Sequence Type | Inc-Type Methylase | Inc-Type Carbapenemase | Co-localisation | References | |
|---|---|---|---|---|---|---|
| ArmA (n = 34) | ||||||
| KPC-2 (n = 5) | ST 101 (n = 4) | FII | FII | Yes | [29] | |
| ST 16 (n = 1) | FII | FII | Yes | [29] | ||
| KPC-3 (n = 4) | ST 101 (n = 4) | FII | X3 (n = 1) | No | ||
| L/M (n = 1) | No | |||||
| A/C (n = 1) | No | |||||
| R (n = 1) | No | |||||
| NDM-1 (n = 12) | ST 11 (n = 1) | A/C | A/C | Yes | [26] | |
| ST 16 (n = 2) | A/C | A/C | Yes | [26] | ||
| FII | FII | Yes | [28] | |||
| ST 147 (n = 5) | A/C | A/C | Yes | [26] | ||
| ST 247 (n = 5) | A/C | A/C | Yes | [26] | ||
| ST 395 (n = 1) | A/C | A/C | Yes | [26] | ||
| ST 405 (n = 1) | A/C | A/C | Yes | [26] | ||
| ST 437 (n = 1) | A/C | A/C | Yes | [26] | ||
| Carbapenemase-negative (n = 4) | ST 14 (n = 1) | - | Untypeable | - | ||
| ST 15 (n = 1) | - | FIB | - | |||
| ST 101 (n = 1) | - | R | - | |||
| ST 340 (n = 1) | - | Untypeable | - | |||
| OXA-48 (n = 8) | ST 231 (n = 1) | Untypeable | R | No | ||
| ST 395 (n = 2) | L/M | A/C | No | |||
| ST 437 (n = 3) | FIB | A/C | No | |||
| ST 944 (n = 2) | L/M | A/C | No | |||
| OXA-181 (n = 1) | ST 35 (n = 1) | A/C | A/C | Yes | [37] | |
| RmtF (n = 25) | ||||||
| KPC-2 (n = 8) | ST 231 (n = 8) | FII | B/O | No | This study | |
| NDM-1 (n = 2) | ST 11 | R (n = 1) | R | Yes | [33] | |
| Untypeable (n = 1) | Untypeable | No | ||||
| Carbapenemase-negative (n = 7) | ST 231 (n = 5) | FIB | - | - | [12] | |
| ST 16 (n = 2) | FIB | - | - | |||
| OXA-48 (n = 1) | ST 147 | FIB | L/M | No | ||
| OXA-181 + NDM-5 (n = 1) | ST 147 | R | R (NDM-5), untypeable (OXA-181) | Yes (NDM-5 +RmtF) | [33] | |
| OXA-232 (n = 6) | ST 231 | FIB (n = 5) | colKp3 | No | [12] | |
| Untypeable (n = 1) | A/C | No | ||||
| RmtB (n = 7) | ||||||
| OXA-48 (n = 1) | ST 101 | A/C | A/C | Yes | [37] | |
| OXA-48 + NDM-1 (n = 2) | ST 11 | A/C | Untypeable | No | ||
| ST 101 | FII | FII (OXA-48), untypeable (NDM-1) | Yes (OXA-48 + RmtB) | [28] | ||
| OXA-181 (n = 2) | ST 16 | FII | FII | Yes | [37] | |
| ST 147 | A/C | A/C | Yes | [37] | ||
| OXA-181 + NDM-5 (n = 1) | ST 16 | FII | FII (OXA-181 + NDM-5) | Yes | [37] | |
| OXA-232 + NDM-5 (n = 1) | ST 231 | A/C | Untypeable (OXA-232, A/C (NDM-5) | Yes | [37] | |
| RmtG (n = 1) | KPC-2 | ST 11 | B/O | FIB | No | [12] |
| RmtB + RmtF (n = 1) | ||||||
| OXA-181 + NDM-5 | ST 16 | FII (RmtB), untypeable (RmtF) | FII (OXA-181), untypeable (NDM-5) | Yes (OXA-181+RmtB) | [37] | |
| Non-RMTases (n = 4) | ||||||
| KPC-2 (n = 2) | ST 11 | - | FII | - | ||
| ST 101 | - | FII | - | |||
| KPC-3 (n = 1) | ST 1519 | - | FII | - | ||
| OXA-48 (n = 1) | ST 147 | - | L/M | - |