Table 1.
Physical properties of drug-free/drug-loaded rosin/LO in situ forming gel systems. Results are shown as mean values ± SD, (n = 3).
| Formula | Viscosity (cP) | Injectability (24 Gauge Needle) | |
|---|---|---|---|
| Force (N) | Work (N.mm) | ||
| NRL0 | 191.40 ± 0.36 a | 4.05 ± 0.13 a | 69.57 ± 0.98 |
| NRL1 | 172.23 ± 1.2 b | 3.53 ± 0.49 ab | 59.42 ± 2.78 |
| NRL2.5 | 169.13 ± 0.93 c | 3.46 ± 0.14 b | 60.84 ± 0.64 |
| NRL5 | 136.67 ± 1.62 d | 2.81 ± 0.13 c | 51.36 ± 3.49 |
| NRL10 | 140.30 ± 0.72 e | 2.81 ± 0.17 c | 51.95 ± 2.07 |
| NRL15 | 140.73 ± 1.00 e | 2.92 ± 0.16 c | 52.05 ± 1.60 |
| NRL20 | 143.37 ± 1.32 f | 2.78 ± 0.13 c | 51.94 ± 0.22 |
| DRL0 | 177.57 ± 2.93 a | 3.00 ± 0.29 a | 52.76 ± 1.02 |
| DRL1 | 157.61 ± 2.02 b | 2.52 ± 0.18 ab | 45.87 ± 2.14 |
| DRL2.5 | 158.20 ± 1.15 b | 2.58 ± 0.13 ab | 46.89 ± 1.92 |
| DRL5 | 141.80 ± 2.75 c | 2.57 ± 0.19 ab | 46.19 ± 2.23 |
| DRL10 | 134.17 ± 2.37 d | 2.41 ± 0.22 b | 45.21 ± 2.57 |
| DRL15 | 124.37 ± 0.64 e | 2.37 ± 0.13 b | 43.09 ± 2.10 |
| DRL20 | 122.60 ± 0.26 e | 2.42 ± 0.08 b | 43.76 ± 1.37 |
| DH-RL0 | 624.51 ± 10.39 a | 14.7 ± 1.58 a | 258.2 ± 32.76 |
| DH-RL2.5 | 644.09 ± 3.25 a | 14.90 ± 0.12 a | 262.84 ± 12.52 |
| DH-RL5 | 665.94 ± 10.16 ab | 17.81 ± 0.50 b | 315.69 ± 16.40 |
| DH-RL10 | 684.15 ± 11.85 bc | 21.47 ± 1.48 c | 359.69 ± 30.68 |
The superscripts (a–f) in the column represent a significant difference within the tested formulations (p < 0.05). (No superscript) not determined, DH = doxycycline hyclate.