Table 3.
Release rate for DOX: in vitro release data fitted with different models.
| Nanogel | Conditions for Release a | First Order (k; r2) b |
Higuchi (k; r2) c |
Peppas (k; n; r2) d |
|---|---|---|---|---|
| NG3 | Healthy | 0.026; 0.86 | 0.078; 0.99 | 0.114; 0.17; 0.98 |
| Cancer | 0.043; 0.99 | 0.166; 0.91 | 0.208; 0.36; 0.98 | |
| NG4 | Healthy | 0.019; 0.96 | 0.056; 0.88 | 0.081; 0.37; 0.93 |
| Cancer | 0.107; 0.92 | 0.208; 0.98 | 0.389; 0.17; 0.94 | |
| NG5 | Healthy | 0.087; 0.91 | 0.054; 0.87 | 0.185; 0.10; 0.99 |
| Cancer | 0.176; 0.92 | 0.215; 0.88 | 0.196; 0.41; 0.90 | |
| NG6 | Healthy | 0.032; 0.99 | 0.069; 0.86 | 0.122; 0.39; 0.99 |
| Cancer | 0.065; 0.98 | 0.126; 0.83 | 0.218; 0.30; 0.99 |
a Mimic healthy (pH 7.4 and 37 °C) and cancer (pH 6 and 40 °C) tissue conditions. b Obtained by Equation (4). c Obtained by Equation (5). d Obtained by Equation (6).