TABLE 3.

MIC₅₀s, MIC₉₀s, MIC ranges, and percentages of susceptibility for glycopeptides, everninomycin, quinupristin-dalfopristin, and erythromycin for 4,156 vancomycin-susceptible and 52 vancomycin-resistant enterococci (VRE)

Bacterial species (n) and drug	MIC (μg/ml)			% Susceptiblea
	Range	50%	90%
E. faecalis (3,491)
Vancomycin	0.12–4	1	2	100
Teicoplanin	0.03–1	0.12	0.12	100 (≤4)
LY 333328	0.03–16	1	2	99 (≤4)
Everninomicin	0.015–2	0.25	1	100 (≤4)
Quinupristin-dalfopristin	0.03–64	4	8	25 (≤2)
Erythromycin	0.03–≥256	2	≥256	53
E. faecalis VRE (2)
Vancomycin	256
Teicoplanin	16–128
LY 333328	2
Everninomicin	0.5–1
Quinupristin-dalfopristin	4–8
Erythromycin	≥256
E. faecium (552)
Vancomycin	0.03–4	0.5	2	100
Teicoplanin	0.03–1	0.25	0.25	100
LY 333328	0.03–2	0.5	1	100
Everninomicin	0.015–2	0.5	1	100
Quinupristin-dalfopristin	0.25–32	0.5	2	92
Erythromycin	0.03–≥256	8	≥256	25
E. faecium VRE (22)
Vancomycin	8–≥256	≥256	≥256	0
Teicoplanin	0.12–256	32	128	27
LY 333328	0.12–2	1	2	100
Everninomicin	0.12–1	0.5	1	100
Quinupristin-dalfopristin	0.25–8	0.5	2	91
Erythromycin	1–≥256	≥256	≥256	5
Other species (114)
Vancomycin	0.25–4	0.5	4	100
Teicoplanin	0.03–0.5	0.12	0.5	100
LY 333328	0.03–2	0.25	1	100
Everninomicin	0.06–2	0.5	1	100
Quinupristin-dalfopristin	0.06–8	1	4	87
Erythromycin	0.03–≥256	2	≥256	51
Other species VRE (27)
Vancomycin	8	8	8	0
Teicoplanin	0.25–0.5	0.25	0.5	100
LY 333328	0.25–1	0.5	1	100
Everninomicin	0.12–2	0.5	1	100
Quinupristin-dalfopristin	1–4	2	2	96
Erythromycin	0.03–≥256	1	≥256	81

^aCriteria are those published by the NCCLS. The MIC breakpoints chosen in case no criteria were given by the NCCLS were those of the class representatives (vancomycin for teicoplanin and LY333328; erythromycin for quinupristin-dalfopristin) or optional (everninomicin) and are given in parentheses.