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. 2022 Mar 25;21:84. doi: 10.1186/s12943-022-01536-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Famitinib facilitates PD-1 blockade to enhance antitumor immunity in a safe manner in vivo. A Study design and tumor growth curve in each treatment group. (n = 10 per group). B-C Tumor weight on the final day and mouse weight during treatment of each group as described above. D Proportion of CD8⁺ T cells among CD45⁺ cells and perforin⁺ cells among CD8⁺ T cells as assessed by flow cytometry. E Granzyme B and perforin expression as quantified by immunohistochemistry. F-G CD8⁺ and PD-L1⁺ cells as quantified by immunohistochemistry. Representative images of CD8 and PD-L1 staining are shown, with the mean cell number per HPF (800X) indicated. HPF, high-power field. Scale bars, 100 μm