Table 3.
Top 12 upstream regulators (acute-phase response signaling).
| Upstream Regulator | Molecule Type | p-Value of Target Molecules in Dataset | Target Molecules in Dataset |
|---|---|---|---|
| HNF1A | transcription regulator | 1.05 × 10−14 | AGT, AHSG, APOH, ATP, C1S, C4BPA, F2, HPX, ITIH4, SERPINA1, SERPING1, TTR |
| IL6 | cytokine | 1.24 × 10−13 | A2M, AGT, APOA1, ATP, CP, FN1, HP, HPX, ORM1, SERPINA1, SERPINA3, TF, TTR |
| HNF4A | transcription regulator | 1.1 × 10−10 | AGT, AHSG, APOA1, APOH, ATP, C1S, CP, HPX, ITIH4, ORM1, ORM2, SERPINA1, SERPINA3, TF, TTR |
| Tcf 1/3/4 | group | 1.66 × 10−8 | AHSG, APOH, TTR |
| Hmgn3 | other | 3.26 × 10−8 | AHSG, APOA1, SERPINA1, TTR |
| OSM | cytokine | 4.43 × 10−8 | A2M, C1S, C4BPA, FN1, HP, SERPINA1, SERPINA3, SERPING1 |
| CEBPB | transcription regulator | 8.56 × 10−8 | AGT, CP, FN1, HP, HPX, ORM1, SERPINA1, TF |
| STAT1 | transcription regulator | 1.21 × 10−7 | A2M, AGT, APOA1, C1S, FN1, SERPINA3, SERPING1 |
| STAT3 | transcription regulator | 1.66 × 10−7 | A2M, AGT, AHSG, ATP, FN1, HP, SERPINA1, SERPINA3 |
| IL6ST | transmembrane receptor | 6.29 × 10−7 | A2M, HP, HPX, ORM1 |
| TNF | cytokine | 1.13 × 10−6 | A2M, AGT, APOA1, ATP, CP, FN1, HP, ORM1, SERPINA3, SERPIND1, TF |
| IL6R | transmembrane receptor | 1.58 × 10−6 | A2M, FN1, HP, SERPINA3 |