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. 2022 Feb 23;15(3):279. doi: 10.3390/ph15030279

Table 1.

Coformers and molar ratios between the APIs, and coformers and water tested to produce the THELES. X = 2, 4, 6, 8, 10.

API Coformer Molar Ratio (API:Cof:H2O)
CLP/TLB TRIS 1:1:X
CLP/TLB TRIS 1:2:X
CLP/TLB ARG 1:1:6
CLP/TLB ARG 1:1:8
CLP/TLB ARG 1:1:10
CLP/TLB ARG 1:2:8
CLP/TLB CIT/MAL/ASC/PABA/TRY 1:1:8
CLP/TLB CIT/MAL/ASC/PABA/TRY 1:1:10

CLP—chlorpropamide; TLB—tolbutamide; TRIS—tromethamine; ARG—L(+)-arginine; TRY—L-tryptophan; CIT—citric acid; MAL—malic acid; ASC—ascorbic acid; PABA—p-aminobenzoic acid.