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. 2022 Mar 15;23(6):3175. doi: 10.3390/ijms23063175

Figure 4.

Figure 4

Functional evaluation of the activity and response to pharmacological treatments of the L467F-F508del-CFTR complex allele on heterologous expression systems. The bar graphs show the activity of L467F-F508del-CFTR and, for comparison, of F508del- and L467F-CFTR transiently expressed in CFBE41o− (A) or FRT (B) cells stably expressing the HS-YFP. CFTR activity was determined as a function of the YFP quenching rate following iodide influx in cells treated for 24 h with DMSO alone (vehicle), or Luma (3 µM), or Elexa (3 µM), or Elexa/Teza (3 µM/10 µM).