. 1999 Oct;43(10):2559–2561. doi: 10.1128/aac.43.10.2559

TABLE 2.

Trough cefepime levels and creatinine clearance measured after multiple 2-g doses of cefepime over 12 h (profile B), and trough plasma cefepime concentrations at 48 h predicted by simulated dosing regimens

Patient	CL_CR (ml/min)	C_0h (μg/ml)	C_12h (μg/ml)	C_{48h trough}^a (μg/ml)
Patient	CL_CR (ml/min)	C_0h (μg/ml)	C_12h (μg/ml)	6 g/day^b	1 g/4 h^c
2	128.4	2.6	2.1	29.8	9.6
3	87.6	5.4	4.0	52.9	29.5
5	127.2	<1.0	<1.0	28.2	7.4
6	195.6	1.4	<1.0	24.9	10.0
7	137.4	3.0	2.8	30.1	13.5
9	146.4	<1.0	<1.0	32.1	13.0
10	115.8	2.0	2.2	35.7	13.2
11	118.8	<1.0	<1.0	42.2	24.1
12	150.6	1.4	1.4	24.3	10.9
13	74.4	6.2	7.7	53.0	33.6
Median	127.8	1.7	1.8	31.1	13.1
Mean	128.2			35.3	16.5
SD	30.5			9.7	8.3

Predicted minimum cefepime concentration after 48 h.

Simulated continuous infusion of 6 g of cefepime per 24 h with an initial 0.5-g loading dose.

Simulated 3-min infusion of 1 g of cefepime every 4 h.