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Genomic analysis of AML cell lines. Copy number states for chromosome 5 (above) and chromosome 16 (below) of IRX1-positive cell lines CMK, M-07e, MKPL-1, and UT-7, and of IRX3/IRX5-positive AML cell lines MEGAL and OCI-AML3 were determined by genomic profiling analysis. A copy number gain for IRX1 (located at 5p15) was detected in MKPL-1 and OCI-AML3. Amplification of FTO, IRX3, and IRX5 (16q12) was detected among multiple complex chromosome 16 rearrangements in MEGAL.
