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. 2022 Mar 7;4(2):fcac052. doi: 10.1093/braincomms/fcac052

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Voxel-wise VBM association of decreased grey matter volume with dementia in NACC data (N = 129). Results using a mask of the entire grey matter, thresholded at T-stat = 3.16 (P = 0.001) and surviving a cluster-wise false discovery rate threshold of 0.05. (A) Strong associations present in the medial temporal lobe, with stronger associations in the left hemisphere. (B) Zoomed-in voxel-wise maps in left hemisphere with outlines of Harvard–Oxford atlas regions of the hippocampus (middle structure), amygdala (top structure) and parahippocampus (bottom structure) illustrating degree of overlap between thresholded T-statistic maps and these regions. Voxel-wise associations of grey matter volume with dementia adjusted for TIV, age, sex, education, years from MRI to death, ADNP, hippocampal sclerosis, CAA, Lewy bodies and atherosclerosis. VBM, voxel-based morphometry; TIV, total intracranial volume; ADNP, Alzheimer's disease neuropathology; CAA, cerebral amyloid angiopathy.