Table 2.

Multiple linear regression results for ROI volumes across the various demographic and neuropathological measures for the NACC data (N = 129)

Regions	Hippocampus				Amygdala				Parahippocampus
Variables	Semi-Part.	% Var. Exp.	T-stat	P-value	Semi-Part.	% Var. Exp.	T-stat	P-value	Semi-Part.	% Var. Exp.	T-stat	P-value
Demographic
Dementia status at MRI	−0.28	7.78	−4.15	<0.001	−0.29	8.24	−4.30	<0.001	−0.28	7.73	−3.91	<0.001
Age	−0.27	7.51	−4.08	<0.001	−0.24	5.95	−3.65	<0.001	−0.25	6.30	−3.52	<0.001
Sex	0.05	0.20	0.67	0.5	−0.04	0.18	−0.64	0.5	−0.12	1.35	−1.62	0.1
Years education	0.13	1.59	1.88	0.06	0.12	1.42	1.78	0.08	0.04	0.12	0.49	0.6
Years MRI to death	0.11	1.25	1.67	0.1	0.09	0.88	1.41	0.2	0.11	1.10	1.48	0.1
TIV	0.19	3.61	2.84	0.005	0.19	3.50	2.80	0.006	0.15	2.28	2.13	0.04
Pathology
ADNP	−0.06	0.41	−0.96	0.3	−0.15	2.31	−2.27	0.03	−0.06	0.35	−0.83	0.4
Hippocampal sclerosis	−0.31	9.73	−4.65	<0.001	−0.19	3.42	−2.77	0.006	−0.17	2.79	−2.35	0.02
Lewy bodies	−0.04	0.13	−0.54	0.6	−0.17	2.92	−2.56	0.01	−0.09	0.79	−1.25	0.2
CAA	−0.03	0.08	−0.44	0.7	0.12	1.46	1.81	0.07	0.05	0.23	0.68	0.5
Atherosclerosis	−0.07	0.44	−0.98	0.3	−0.08	0.67	−1.22	0.2	−0.08	0.59	−1.08	0.3
R 2	0.47				0.48				0.41

Bold denotes P < 0.05.

TIV, total intracranial volume; ADNP, Alzheimer’s disease neuropathology; CAA, cerebral amyloid angiopathy; Semi-Part., semi-partial correlation coefficient; Var. Exp., unique variance explained.