Table 1.
Characteristics of the study participants.
| Characteristics by SARS-CoV-2 Immunity |
HIV-1-Infected (n = 82) |
HIV-1-Uninfected (n = 77) |
p Value |
|---|---|---|---|
| BNT162b2 mRNA vaccinated (n = 110) | |||
| n | 50 | 60 | |
| age (years) | 55 (46–60) | 42 (30–53) | <0.0001 |
| female/male ratio | 16/34 | 28/32 | 0.171 |
| days post first boost | 37 (21–53) | 26 (16–68) | 0.710 |
| prime-boost interval | 42 (23–42) | 23 (21–42) | 0.0024 |
| CD4 count | 634/µL (370–906) | / | / |
| CD4 count below 300/µL | 5/50 | / | / |
| viral load(copies/mL) | <20 (<20−20) | / | / |
| COVID-19 infected (n = 43) | |||
| n | 26 | 17 | |
| age (years) | 44 (39–57) | 48 (35–59) | 0.897 |
| female/male ratio | 9/17 | 6/11 | >0.999 |
| days post infection | 68 (37–140) | 72 (22–131) | 0.327 |
| CD4 count | 551/µL (382–761) | / | / |
| CD4 count below 300/µL | 3/26 | / | / |
| viral load (copies/mL) | <20 (<20–<20) | / | / |
| SARS-CoV-2 NI (n = 6) | |||
| n | 6 | / | / |
| age (years) | 40 (34–56) | / | / |
| female/male ratio | 1/5 | / | / |
| CD4 count | 571 (429–921) | / | / |
| CD4 count below 300/µL | 0/6 | / | / |
| viral load (copies/mL) | <20 (<20–30) | / | / |
NI = non-immune subjects were SARS-CoV-2 seronegative, SARS-CoV-2 unvaccinated subjects without history of COVID-19. Statistical comparisons between HIV-1-infected and HIV-1-uninfected were performed using Mann–Whitney U-test (age and days post first boost/infection) or Fisher’s exact test (female/male ratio). Indicated numbers for age, CD4 counts, and viral load represent medians with IQR in brackets.