Effect of curcumin-enriched rHDLs on MGO cytotoxicity in cerebral endothelial cells. The cells were pre-treated with different concentrations of rHDLs (H), curcumin (C), and curcumin-enriched rHDLs (Cur-rHDLs) for 1 h before the addition of 2 mM MGO for 24 h. (a) H: 50μg/mL, C: 0.03 μM and Cur-rHDL: 50 μg/mL + 0.03 μM. (b) H: 80 μg/mL, C: 0.048 μM and Cur-rHDLs: 80 μg/mL + 0.048 μM. (c) H: 100 μg/mL, C: 0.06 μM and Cur-rHDLs: 100 μg/mL + 0.06 μM (d) H: 200 μg/mL, C: 0.12 μM and Cur-rHDLs: 200 μg/mL + 0.12 μM. Data are presented as mean ± SD of three independent experiments (n = 3). #### p < 0.0001, ## p < 0.01 as compared to control, $$ p < 0.01, $$$$ p < 0.0001 as compared to MGO+H, &&&& p < 0.0001 as compared to MGO and **** p ˂ 0.0001 as compared to MGO+C.