Table 1.

Percentage of diagnosed IMDs in various cohorts of epilepsy patients.

Reference	Cohort of Patients	Percentage of IMDs among All Diagnoses	Diagnostic Method
[19]	197 children with epilepsy, abnormal metabolic investigations was an exclusion criterion	13%	ES
[20]	293 patients with variable epilepsy phenotypes	21.5%	ES
[13]	patients with variable epilepsy phenotypes	38%	TruSight One panel, Illumina
[21]	180 patients with early-life epilepsy (onset ≤ 5 years)	25%	Gene panel of 620 known epilepsy genes
[17]	38 patients with progressive myoclonic epilepsies	62.5%	ES
[22]	150 adult and elderly patients with intellectual disability and epilepsy	18%	TruSight One panel, Illumina/ES

ES—exome sequencing.