Table 1.
Commonly used polymers as drug carrier materials for coaxial electrospun nanofibre drug delivery systems.
| Materials | Properties | Applications | References |
|---|---|---|---|
| Polyvinyl alcohol (PVA) | Biocompatibility, non-toxicity, non-carcinogenicity, flexibility, bioadhesiveness, high solubility in water, non-solubility in organic solvents, thermal stability | The core of pH-sensitive fibre loading DOX; the shell of thermally activated fibre | Yan et al. [32], Fazio et al. [33] |
| Polyethylene oxide (PEO) | Low toxicity, high viscosity, solubility in water and many organic solvents, thermoplastic, crosslink ability | The core of sonication-triggered fibre; the shell of fibre loading quercetin nanoparticles | Birajdar and Lee [34], Wen et al. [35] |
| Polyvinylpyrrolidone (PVP) | Biocompatibility, bioadhesiveness, high solubility in water and various organic solvents, high hygroscopicity, good affinity to various polymers | PVP K90 and PVP K10 are designed as core and shell, respectively, in one ultrathin nanofibre | Li et al. [29] |
| Poly-ε-caprolactone (PCL) | Biocompatibility, low degradation rate, high solubility in organic solvents, good elasticity, low cell adhesion | The shell of temperature-responsive nanofibre | Li et al. [36] |
| Polylactic-co-glycolic acid (PLGA) | Biocompatibility, biodegradability, tuneable mechanical property, FDA-approved polymer | The core of fibre membrane containing DOX; the shell of fibre with proteins and peptides | Guo et al. [37], Yu et al. [38] |
| Polyurethane (PU) | Biocompatibility, good abrasion and heat resistance, complex shapes and bonding, flexural endurance | The shell of fibre with DOX and folic acid in the core | Farboudi et al. [39] |
| Chitosan | Biocompatibility, biodegradability, non-toxicity, antifungal and antibacterial effects, oral absorption enhancer | PNIPAAm-grafted chitosan designed as the core of temperature-sensitive fibre | Farboudi et al. [40] |
| Eudragit | Low toxicity via the subcutaneous route L100: dissolution above pH 6.0 S100: dissolution above pH 7.0 |
Eudragit S100 designed as the shell of colon-targeted nanofibre | Jia et al. [41] |