Table 1.

Summary of patient characteristics, dosing, results, and weight trends.

Patient Information	Baseline	Injections (Injection Number: Age, Total Units/LPt, (Units/kg/LPt))	Results as Observed/Reported by Care Takers and Physician	Weight Trends (Injection Number: Weight)
Patient 1 Dx: mixed spastic/dystonic quadriplegic CP GMFCS: IV	General: Mouth open 75% of the time. Feeding: difficulty inserting spoon into mouth when feeding Speech: vocalizing monosyllabic sounds such as “ah, ah” Quality of Life: difficulty working with speech therapist	#1: 1 y 11 mo; 5 units /LPt (0.47 units/kg/LPt) #2: 2 y 2 mo; 10 units/ LPt (0.84 units/kg/LPt) #3: 3 y 7 mo; 10 units/ LPt (0.87 units/kg/LPt)	#1: Mouth open 40% of time, improved ease of feeding/clearing spoon when inserting into mouth #2: improved ability to close mouth, able to chew food and eat without breaks, ability to close mouth further improved by 50% #3: continued good mouth closure, improved speech, starting to close lips to swallow	#1: 10.4 kg #2: 11.6 kg #3: 10.5 kg Last Documented Age: 4 y 9 mo Weight: 16 kg
Patient 2 Dx: dyskinetic quadriplegic CP GMFCS: V	General: inability to control facial muscles, difficulty closing mouth, mouth remains open 80% of time but able to close mouth with masseter stimulation Feeding: difficulty chewing food Speech: has a few words, difficulty speaking Quality of Life: difficulty expressing emotions	#1: 9 y 0 mo; 10 units /LPt (0.625 units/kg/LPt) #2–7: 9 y 4 mo–11 y 1 mo; 10–15 units /LPt (0.63–0.75 units/kg/LPt) * #8: 11 y 6mo; 20 units/ LPt (1 unit/kg/LPt) #9: 11 y 10 mo; 20 units/LPt (0.99 units/kg/LPt)	# 1: starting to talk more, mouth appears more relaxed and can now close mouth volitionally # 2–8: improved ability to close mouth, improved quality and quantity of speech, takes less time to eat, mouth open 20% of time with further (60%) improvement after more injections, decreased tongue thrust from a severity of 9/10 to 2/10 on a Likert scale #9: difficulty closing mouth after longer than usual interval between injections (5 months), jaw is noted to be open throughout clinic visit	#1 16.1 kg #2–7: 15.85–19.95 kg #8: 19.5 kg #9: 20.3 kg Last Documented Age: 12 y 3 mo Weight: 38kg
Patient 3 Dx: mixed spastic/dystonic quadriplegic CP GMFCS: II	General: able to close mouth on command, but maintains it open for most of the exam Feeding: chokes and coughs when swallowing liquids while sitting Speech: difficult to understand, relies on gestures and signs to communicate Quality of Life: excessive drooling, saliva on clothes with bib change 15 times per day	#1: 7 y 2 mo; 20 units/ LPt (1.05 units/kg/LPt) #2: 7 y 5mo; 20 units/LPt (1.01 units/kg/LPt) #3: 7 y 9 mo; 20 units/LPt (0.96 units/kg/LPt) #4: 8 y 2 mo; 20/units/ LPt (0.9 units/kg/LPt)	#1: improved ability to close mouth and speak, appeared less frustrated with better behavior, bib change 5 times per day #2-3: improved ability to close mouth and speak #4: starting to use straw to drink thick liquids, injection effect lasting longer, and improved oral intake	#1: 18.9 kg #2: 19.7 kg #3: 20.9 kg #4: 22 kg Last Documented As per #4
Patient 4 Dx: mixed spastic/dystonic quadriplegic CP GMFCS: IV	General: poor motor control of the mouth Feeding: eats soft diet and takes longer than typical to finish meals Speech: can speak 1–2 words together but difficult to articulate Quality of Life: excessive drooling	#1: 4 y 7 mo; 10 units/ LPt (0.63 units/kg/LPt) #2: 5 y 0 mo; 10 units/LPt (0.6 units/kg/LPt)	#1: improved chewing and overall eating, improved articulation, parents can understand speech 100% of the time and strangers can understand speech 60% of the time #2: improvement in chewing, swallowing, and amount of PO intake	#1: 14.1 kg #2: 14.6 kg Last Documented Age: 6 y 5 mo Weight: 16.3 kg
Patient 5 Dx: mixed spastic/dystonic quadriplegic CP GMFCS: V	General: frequent bruxism and mal-alignment of the jaw Feeding: difficulty with chewing and eating Quality of Life: pain with teeth grinding	#1 28 y/o; 20 units/LPt (0.44 units/kg/LPt)	#1: improved jaw alignment, improved ability to chew and eat, improved teeth approximation, able to keep food in mouth while eating, slight increase in drooling, pain resolved	#1: 45.4 kg Last Documented Age: 28 y/o., (3 months post injections) Weight: 45.81

* Time interval between injections ranged from three to five months; LPt = Lateral Pterygoid.