Figure 4.

Overlay of docked ligand structures (in stick and balls representation) on human MT1 ((A), with agomelatine) and MT2 ((B), with ramelteon) melatonin receptors as they are found in the crystal complexes. The sidechain of some residues considered key in the binding pocket are depicted as reference. High similarity in the binding sites of both receptors is notable. Oxygen atoms are in red color, nitrogen atoms are in blue color.