Figure 1.

Human inborn errors of and auto-Abs to cytokines underlying infectious diseases. This figure illustrates the key actions of four of the cytokines reviewed in this article. Gene products mutated in patients with infectious diseases are shown in red. Auto-Abs neutralizing the cytokines are also shown. For the sake of simplicity, only the most important cell types involved in the biology of each of these cytokines are shown. Molecules, including cytokines and their receptors, are also shown only on key cell types. A more detailed description of the biology of each cytokine can be found in specific reviews.