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. 2022 Mar 4;12(3):402. doi: 10.3390/jpm12030402

Figure 2.

Figure 2

Tumor localization based on tumor-associated parameters. MGMT-methylated tumors and tumors with a lower Ki-67 value were lateralized to the left hemisphere. In contrast, MGMT-unmethylated tumors and tumors with mutation of IDH1 were found to be lateralized to the right hemisphere. IDH1-mutant tumors were located in the frontal lobe, whereas IDH wild-type tumors were located in the frontal and temporal lobes. Tumors with the proneural gene expression subtype and tumors with an absent loss of PTEN frequently occurred in the frontal lobe. MGMT-methylated tumors were located in the (left) frontal and left temporal lobes. In contrast, MGMT-unmethylated tumors were located in the insular lobe. Tumors revealing EGFR amplification and EGFRvIII-mutated tumors involved the frontal, left temporal and parietal regions. Temporal location was associated with IDH wild-type tumors. Abbreviations: EGFR+, EGFR amplification; EGFRvIII+, EGFRvIII mutation; IDH1+, IDH1 mutation; IDH-wt, IDH wildtype; Ki-67, Kiel-antigen Nr.67; MGMT-, MGMT promotor unmethylated; MGMT+, MGMT promotor methylated.