Table 2.
Comparison of hematological indices between JAK inhibitors and controls.
| Variables | JAK Inhibitors (n = 123) | Healthy Controls (n = 80) | p-Value |
|---|---|---|---|
| Whole blood cell count | |||
| White blood cell (×103/µL) | 8.0 ± 1.9 | 5.4 ± 1.3 | <0.001 |
| Hemoglobin (g/dL) | 12.2 ± 1.2 | 12.8 ± 1.2 | <0.001 |
| Platelet (×103/µL) | 287.3 ± 80.1 | 239.9 ± 65.1 | <0.001 |
| Neutrophil (%) | 68.0 ± 10.0 | 54.1 ± 10.7 | <0.001 |
| Lymphocyte (%) | 22.0 ± 8.6 | 35.4 ± 9.9 | <0.001 |
| Neutrophil (×103/µL) | 5.6 ± 1.9 | 3.0 ± 1.0 | <0.001 |
| Lymphocyte (×103/µL) | 1.7 ± 0.6 | 1.9 ±0.6 | 0.027 |
| Hematological indices | |||
| SII | 928.7 (587.9, 1385.6) | 380.5 (236.6, 543.6) | <0.001 |
| NHL score | 0.281 (0.179, 0.400) | 0.121 (0.087, 0.169) | <0.001 |
| NLR | 3.431 (2.201, 4.736) | 1.566 (1.125, 2.146) | <0.001 |
| PLR | 174.6 (133.6, 235.0) | 130.8 (101.6, 164.0) | <0.001 |
p-values were calculated by Student’s t-test or Mann–Whiney U test. Data were described as means (standard deviation) or medians (interquartile range) for quantitative variables. Abbreviations: SII, systemic immune-inflammation index; NHL, neutrophil-to-hemoglobin and lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.