TABLE 1.

Dapsone pharmacokinetic parameters by dosing group

Dosage	Age (yr)	Tmax (h)	Cmax (μg/ml)	AUC0–∞ (μg · h/ml)	CL/F (liter/kg/h)	V/F (liter/kg)	t1/2 (h)
1 mg/kg daily (n = 10)	3.0 (0.7–11.1)	2 (1–4)	1.39 (0.50–2.33)	19.6 (9.8–98.6)	0.0541 (0.0104–0.1021)	1.15 (0.50–2.32)	15.8 (9.0–33.0)
2 mg/kg daily (n = 11)	2.0 (0.3–12.2)	2 (1–8)	3.09 (1.86–3.93)	49.1 (30.3–121.7)	0.0363 (0.0165–0.0650)	1.20 (0.63–1.63)	18.3 (14.3–34.5)
4 mg/kg weekly (n = 10)	3.2 (0.9–12.7)	4 (1–6)	3.54 (2.65–4.43)	140.8 (42.8–267.9)	0.0278 (0.0155–0.0906)	0.94 (0.79–1.51)	25.7 (7.1–40.3)
Total (n = 31)	2.8	2.0			0.0365	1.13	22.2