FIG. 1.

Study of activity of L-nystatin at cumulative doses ranging from 10 to 35 mg/kg compared with those of amphotericin B and empty liposomes (control). Plots are of cumulative mortality against time after AF65 infection and treatment with L-nystatin. □, L-nystatin at 5 mg/kg on days 1 to 7; ●, L-nystatin at 5 mg/kg on days 1, 2, 4, and 7; ○, L-nystatin at 2.5 mg/kg on days 1 to 7; ▴, L-nystatin at 2.5 mg/kg twice daily on days 1, 2, 4, and 7; ◊, L-nystatin at 2.5 mg/kg on days 1, 2, 4, and 7; ■, amphotericin B at 5 mg/kg days on 1, 2, 4, and 7; ×, no active treatment.